Distinct methylation profile of mucinous ovarian carcinoma reveals susceptibility to proteasome inhibitors
نویسندگان
چکیده
منابع مشابه
Mucinous epithelial ovarian carcinoma.
Mucinous tumours involving the ovary may be benign, borderline, or malignant. Malignant tumours may be primary or metastatic. Differentiation between primary and metastatic involvement of the ovary is critical for optimal patient management. Even among skilled pathologists, this distinction can be problematic, as can the distinction between borderline ovarian tumour of intestinal type and well-...
متن کاملTargeting SRC in mucinous ovarian carcinoma.
PURPOSE Mucinous ovarian carcinomas have a distinct clinical pattern compared with other subtypes of ovarian carcinoma. Here, we evaluated (i) stage-specific clinical significance of mucinous ovarian carcinomas in a large cohort and (ii) the functional role of Src kinase in preclinical models of mucinous ovarian carcinoma. EXPERIMENTAL DESIGN A total of 1,302 ovarian cancer patients including...
متن کاملMolecular analysis of ovarian mucinous carcinoma reveals different cell of origins
It is believed that a subset of primary ovarian mucinous tumors is derived from mature teratomas [1-5]. To confirm this, we performed microsatellite genotyping using a variety of short tandem repeat makers and analyzed allelotypes of 8 mucinous tumors (4 mucinous carcinomas, 3 atypical proliferative mucinous tumors and 1 mucinous cystadenoma) associated with a teratoma to determine whether they...
متن کاملPure Mucinous Carcinoma of the Breast
Mucinous carcinoma of the breast is a well differentiated, rare histological type of invasive ductal carcinoma, seen in oldest median age (69 years). We describe a case of a 60 yr old female with large right breast mass of 10 years duration with no nodal involvement. The reasons to present this case are 1) Because of its rarity. 2) Despite having a large tumour size, the axillary lymph node ...
متن کاملMethylation profile in penile carcinoma reveals unique signature relative to surround tissue and HPV status
Background Penile carcinoma (PeCa) is an important public health problem in poor and developing countries. Despite the unpredictable behavior and aggressive treatment, there are few data on molecular and epigenetic mechanisms reported in PeCa. The aim of this study was to identify epigenetic profile in tumors and surrounding tissue as well as to identify molecular markers in PeCa, according to ...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2018
ISSN: 0020-7136
DOI: 10.1002/ijc.31324